翻訳と辞書 Words near each other ・ Acetrizoic acid ・ Acetropis gimmerthalii ・ Aceturic acid ・ Acetyl ・ Acetyl activating enzyme ・ Acetyl bromide ・ Acetyl chloride ・ Acetyl cyanide ・ Acetyl fluoride ・ Acetyl hexapeptide-3 ・ Acetyl iodide ・ Acetyl tributyl citrate ・ Acetyl-CoA ・ Acetyl-CoA C-acetyltransferase ・ Acetyl-CoA C-myristoyltransferase ・ Acetyl-CoA carboxylase ・ Acetyl-CoA hydrolase ・ Acetylacetone ・ Acetylacetone-cleaving enzyme ・ Acetylajmaline esterase ・ Acetylalkylglycerol acetylhydrolase ・ Acetylated distarch adipate ・ Acetylated lanolin alcohol ・ Acetylated wood ・ Acetylation ・ Acetylcarnitine ・ Acetylcarnosine ・ Acetylcholine ・ Acetylcholine receptor ・ Acetylcholinesterase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Acetyl-CoA carboxylase ： ウィキペディア英語版 Acetyl-CoA carboxylase Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is a multi-subunit enzyme in most prokaryotes and in the chloroplasts of most plants and algae, whereas it is a large, multi-domain enzyme in the endoplasmic reticulum of most eukaryotes. The most important function of ACC is to provide the malonyl-CoA substrate for the biosynthesis of fatty acids. The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification. The human genome contains the genes for two different ACCs — ACACA and ACACB. == Structure == Prokaryotes and plants have multi-subunit ACCs composed of several polypeptides encoded by distinct genes. Biotin carboxylase (BC) activity, biotin carboxyl carrier protein (BCCP), and carboxyl transferase (CT) activity are each contained on a different subunit. The stoichiometry of these subunits in the ACC holoenzyme differs amongst organisms.〔 Humans and most eukaryotes have evolved an ACC with CT and BC catalytic domains and biotin carboxyl carrier domains on a single polypeptide. ACC functional regions, starting from the N-terminus to C-terminus are the biotin carboxylase (BC), biotin binding (BB), carboxyltransferase (CT), and ATP-binding (AB). AB lies within BC. Biotin is covalently attached through an amide bond to the long side chain of a lysine reside in BB. As BB is between BC and CT regions, biotin can easily translocate to both of the active sites where it is required. In mammals where two isoforms of ACC are expressed, the main structural difference between these isoforms is the extended ACC2 N-terminus containing a mitochondria targeting sequence.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Acetyl-CoA carboxylase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.